This paper puts forward an ontology that is indebted to QBism, Kant, Bohr, Schrödinger, the philosophy of the Upanishads, and the evolutionary philosophy of Sri Aurobindo. Central to it is that reality is relative to consciousness or experience. Instead of a single mind-independent reality, there are different poises of consciousness, including a consciousness to which “we are all really only various aspects of the One”. This ontology helps clear up unresolved issues in the philosophy of science, such as arise from (...) the reification of quantum states or from disregard of the universal context of science, which is human experience. It further helps clear up unresolved issues in the philosophy of mind, in particular the problem of intentionality and the dilemma posed by the mutual inclusion of self and world. (shrink)

Sophocles, Antigone 853–856, Jebb's text: προβσ' π' σχατον θρσους ψηλν ς Δκας βθρον προσπεσες, τκνον, πολ.

This book has grown out of eight years of close collaboration among its authors. From the very beginning we decided that its content should come out as the result of a truly common effort. That is, we did not "distribute" parts of the text planned to each one of us. On the contrary, we made a point that each single paragraph be the product of a common reflection. Genuine team-work is not as usual in philosophy as it is in other (...) academic disciplines. We think, however, that this is more due to the idiosyncrasy of philosophers than to the nature of their subject. Close collaboration with positive results is as rewarding as anything can be, but it may also prove to be quite difficult to implement. In our case, part of the difficulties came from purely geographic separation. This caused unsuspected delays in coordinating the work. But more than this, as time passed, the accumulation of particular results and ideas outran our ability to fit them into an organic unity. Different styles of exposition, different ways of formalization, different levels of complexity were simultaneously present in a voluminous manuscript that had become completely unmanageable. In particular, a portion of the text had been conceived in the language of category theory and employed ideas of a rather abstract nature, while another part was expounded in the more conventional set-theoretic style, stressing intui tivity and concreteness. (shrink)

This article presents the new German law on advance directives from 1 September 2009. The history of the parliamentary process of this law is described, the present regulations are explained, their relevance for medical practice discussed and shortcomings are identified. Finally, the new law is compared with other regulations in the international context. Previously established legal practice in Germany has now become largely confirmed by the new law: An advanced directive must be respected in any decision concerning medical treatment, regardless (...) of the stage of the illness. It can be informally revoked at any time, even with limited decision-making capacity. Nobody may be obliged to issue a directive in any way. Advance directives do not need notarisation or routine updating after certain time intervals. Provided that the patient, who is no longer mentally competent, has issued a lasting power of attorney, or provided that the patient has been appointed a healthcare proxy by the courts, this authorised surrogate must assert the patient's will. The role of the guardianship court is clarified: it only needs to be involved in cases of disagreement as to the patient's will. The new German law thus combines more legal certainty with a liberal emphasis on patient autonomy and flexible, adaptable regulations. (shrink)

We compare a “Mach-Zehnder interferometer in time” for cold neutrons with its well-known spatial counterpart and demonstrate the intimate connection between space and time for both setups. Further, we outline a combined space-time interferometer, which coherently splits a wavepacket in longitudinal and lateral direction. On the way towards time interferometry “neutron computer holography” seems to be an attractive application. It allows the three-dimensional reconstruction of an object from the scattered intensity, but in contrast to holography with light, there is no (...) need for a reference wave. On the other hand, the possible resolution is worse than in the light case. (shrink)

We give picture-covariant formulations of the equations of motion for observables and states such that the Hamiltonian operator is transformed asH-0304;=U(t)HU † (t) under a time-dependent unitary transformationU(t). Next, we consider the explicit and implicit covariance of Heisenberg's equations of motion for observables with respect to general transformations of coordinate operators. Most of our representation is spread out over a number of textbooks and articles, where the subject has been considered with greater or lesser clarity from different points of view.

James E Cooper¹, Uwe Christians², Alexander C Wiseman¹¹Division of Renal Diseases and Hypertension, Transplant Center, ²iC42 Integrated Solutions in Systems Biology for Clinical Research and Development, University of Colorado Denver, Aurora, CO, USA: Everolimus is a novel target of rapamycin -I analog that has recently been approved in combination with cyclosporine A and steroids for use in the prevention of organ rejection in kidney transplant recipients. Compared with rapamycin, everolimus is characterized by a shorter half-life and improved bioavailability. Prior to (...) US Food and Drug Administration approval, a number of Phase II and III clinical trials were undertaken to evaluate the effectiveness of everolimus in combination with calcineurin inhibitors for preventing acute rejection and promoting allograft survival in kidney transplant recipients. In this report, we review the pharmacokinetic properties of everolimus, the clinical efficacy studies that led to its approval for use in kidney transplantation, as well as reported data on patient safety and tolerability associated with its use.Keywords: mTOR inhibitors, kidney transplantation, everolimus. (shrink)

Based on extensive questionnaire data, this paper focuses on parents’ views about children’s right to decide about participation in research. The data originates from 4000 families participating in a longitudinal prospective screening as 1997. Although current regulations and recommendations underline that children should have influence over their participation, many parents in this study disagree. Most (66%) were positive providing information to the child about relevant aspects of the study. However, responding parents were split about whether or not children should at (...) some point be allowed decisional authority when participating in research: 41.6% of the parents reported being against or unsure. Those who responded positively believed that children should be allowed to decide about blood-sampling procedures (70%), but to a less extent about participation (48.5%), analyses of samples (19.7%) and biological bank storage (15.4%). That as many as possible should remain in the study, and that children do not have the competence to understand the consequences for research was strongly stressed by respondents who do not think children should have a right to decide. When asked what interests they consider most important in paediatric research, child autonomy and decision-making was ranked lowest. We discuss the implications of these findings. (shrink)

When the Oxyrhynchus Papyri of Sophocles' 'ІΧνενταí gave the forms κννηγ[Έ]σω , 1. 44 in Fragmenta Tragica Papyracea, and ΈκκννηγΈσαι, 1. 75, it restored to light a verb which is not acknowledged in the Lexicons, but which had remained, though almost unnoticed, in Phrynichus, Soph. Propar. in Bekker's Anecdota I. p. 48, and Theognostus' Canons in Cramer's Anecdota Oxoniensia II. p. 143. The form could not come from κννηγετΕîν, nor from the Hellenistic verb κννηγεîν, and attention was first drawn to (...) these two authorities by P. Maas in Berl. Philol. Wochenschr. 1912, p. 1075, and by J. Stahl in Rhein. Mus. Vol. LXVIII. p. 307 . I owe these references to Mr. Stuart Jones. (shrink)

When the Oxyrhynchus Papyri of Sophocles' 'ІΧνενταí gave the forms κννηγ[Έ]σω, 1. 44 in Fragmenta Tragica Papyracea, and ΈκκννηγΈσαι, 1. 75, it restored to light a verb which is not acknowledged in the Lexicons, but which had remained, though almost unnoticed, in Phrynichus, Soph. Propar. in Bekker's Anecdota I. p. 48, and Theognostus' Canons in Cramer's Anecdota Oxoniensia II. p. 143. The form could not come from κννηγετΕîν, nor from the Hellenistic verb κννηγεîν, and attention was first drawn to these (...) two authorities by P. Maas in Berl. Philol. Wochenschr. 1912, p. 1075, and by J. Stahl in Rhein. Mus. Vol. LXVIII. p. 307. I owe these references to Mr. Stuart Jones. (shrink)

Due to the potential ethical and psychological implications of screening, and especially inregard of screening on children without available and acceptable therapeutic measures, there is a common view that such procedures are not advisable. As part of an independent research- and bioethical case study, our aim was therefore to explore and describe bioethical issues among a representative sample of participant families (n = 17,055 children) in the ABIS (All Babies In South-east Sweden) research screening for Type 1 diabetes (IDDM).The primary (...) aim is the identification of risk factors important for the development of diabetes and other multifactorial immune-mediated diseases. Four hundred, randomly chosen, participant mothers were asked to complete a questionnaire exploring issues of information, informed consent, bio-material, confidentiality and autonomy, and of prevention/intervention. 293 completed the questionnaire, resulting in a response rate of 73.3%. The majority of questions had the form of 6-point Likert-type response scales (1–6).We found that the majority of respondents felt calm in regard of samples and written material, and also concerning the possibility of their child in the future being identified as having high risk of developing Type 1 diabetes. An important finding concerning access and control of mainly biological data was indicated, with the respondents expressing concern for potential future use. We believe our findings indicate that this kind of empirical studies can substantially contribute to our understanding of bioethical issues of medical research involving genetics. Issues, such as safeguards ensuring theethical criteria of autonomy and respect, were emphasised by our respondents. We believe theissues brought up may promote further discussion, and do suggest issues for consideration by, among others, researchers, bioethicists and Institutional Review Boards. (shrink)

Hermesianax, ap. Athen. 599B, I. 91 = Collectanea Alexandrina p. 100. This is a locus desperatus; but since the reviewer of Collectanea Alexandrina in the Classical Review, XXXIX., p. 192, accepts the idea which underlay my conjecture ξετρνησε, I think of adding to it οѵδϥμνόν τε, which is suggested by Schweighaeuser's οѵδϥμνόν The line will thus run: οѵδϥμνόν τ' ξετρνησε βίον ‘uitam uilem deliciis consumpsit.’ Hesychius has: οѵδαμνός οδένοςλόуου εστ βραύςεύτελής.

Hermesianax, ap. Athen. 599B, I. 91 = Collectanea Alexandrina p. 100. This is a locus desperatus; but since the reviewer of Collectanea Alexandrina in the Classical Review, XXXIX., p. 192, accepts the idea which underlay my conjecture ξετρνησε, I think of adding to it οѵδϥμνόν τε, which is suggested by Schweighaeuser's οѵδϥμνόν The line will thus run: οѵδϥμνόν τ' ξετρνησε βίον ‘uitam uilem deliciis consumpsit.’ Hesychius has: οѵδαμνός οδένοςλόуου εστ βραύςεύτελής.

Mr. Agar in Homerica, Preface ix., has suggested that κακι γλνηι was the original reading, ‘Be off with the evil eye upon you.’ I have searched, but in vain, for any formula of imprecation corresponding to the formula of blessing, τύχγαθι, though I should like to see it in κακι τѵχι of the Treacherous Hound in Agamemnon 1230. Mr. T. C. Snow, objecting to Mr. Agar's alterations of the Homeric text, once suggested to me that we should rather retain the (...) vocative, and translate it, ‘Be off, evil eye.’ Others also may have thought of this, but it does not appear to have got into print. (shrink)

μxs22EF. ρ[…] τει. Professor Hunt thinks that this may be the remains of a verb ending in -εxs22EF or -λxs22EF; read perhaps 'κρινλάτει. The uncompounded verb occurs in col. iv. 1. 8. It is well known that Sophocles is fond of forming new verbs compounded with xs22EFκ. Professor Hunt tells me that this suggestion satisfies the conditions in the Papyrus. Compare κυνηλέσω, 11. 15, 44, and xs22EFκκυνηλxs22EFσαι, 1. 75.

μxs22EF. ρ[…] τει. Professor Hunt thinks that this may be the remains of a verb ending in -εxs22EF or -λxs22EF; read perhaps 'κρινλάτει. The uncompounded verb occurs in col. iv. 1. 8. It is well known that Sophocles is fond of forming new verbs compounded with xs22EFκ. Professor Hunt tells me that this suggestion satisfies the conditions in the Papyrus. Compare κυνηλέσω, 11. 15, 44, and xs22EFκκυνηλxs22EFσαι, 1. 75.

Sophocles, Antigone 853–856, Jebb's text: προβσ' π' σχατον θρσους ψηλν ς Δκας βθρον προσπεσες, τκνον, πολ.